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-   -   How to differentiate driver mutations from common/random mutations and SNPs in cancer (http://seqanswers.com/forums/showthread.php?t=23030)

kumardeep 09-04-2012 02:51 AM

How to differentiate driver mutations from common/random mutations and SNPs in cancer
 
Hi all,

I am working on RNA-seq data ( our own experimental data) for some cancer types of human. I want to know whether the genes found/mapped in the raw data have mutations significantly different from the normal mutations found in the cells. (i.e. distinguish somatic mutations from germline mutations). Also I want to negate significant driver mutations from the SNPs. So what packages are available for this task (what is the protocol exactly) ?. Also, which databases I have to compare my data with to exclude the obvious mutations/variations in my patient samples?

Thanks
Regards
Kumardeep


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