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I learned that estimated false positive SNP rate=1- (observed_ti/tv_ratio-0.5)/(expected_ti/tv_ratio-0.5). In one of our re-sequencing data, the observed ti/tv ratio for coding region is 3.0 (while expected ti/tv ratio for exome is 2.8). But false positive rate can not be negative...
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What do ti and tv stand for? -
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Does anybody know why the false positive SNP rate is estimated as
1- (observed_ti/tv_ratio-0.5)/(expected_ti/tv_ratio -0.5)?
Any reference to this is much appreciated.Comment
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Thanks Nilshomer! I will have a look at the website you pointed at, and hope I can figure out the answer to my question...Originally posted by nilshomer View PostComment
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