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shiloh pl 07-01-2021 12:31 AM

Methylation and enhancer question
 
Hi, thank you for viewing this question. I have a background in biology but not a background in bioinformatics. My question relates to conservation of the positions of enhancers.

I am looking at the supplementary material of a study that says there are methylations at location 90752569 of chromosome 10, defined as a S_Shore (UCSC_CpG_Islands_Name=chr10:90750293-90751108) of the FAS gene (they mention its the FAS gene according to UCSC_RefGene_Name.) Under the column Enhancer it says "NA".

However, on Genecard this location is not the location of FAS. Genecard states location of FAS is "chr10:88948601-88954174 (GRCh38/hg38)chr10:90708358-90713931 (GRCh37/hg19))"

Location 90752569 on chromosome 10 does not seem to fit with FAS but it does with ACTA2 according to Genecard. Genomic Location of ACTA2: chr10:88988929-88997555 (GRCh38/hg38)chr10:90748686-90757312 (GRCh37/hg19)

What is the meaning of this? Is this a methylation of FAS or ACTA2? Is this an enhancer region? Genecard says FAS has an enhancer for ACTA2. (https://www.genecards.org/cgi-bin/ca....pl?gene=ACTA2) I am grateful for an explanation of this.


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