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mateyboy 10-15-2020 11:25 AM

Can somebody more learned than me help explain what these two questions are asking?
So I am tackling an introductory bioinformatics course and I am kind of confused on what the following questions are asking to be honest, not really asking for homework help, but to simply explain how I would go about solving these?

Here is one Q:

I am not sure if I am supposed to draw 5 different trees for the 5 different positions here?

Isn't the answer WWWWW? Cos if you do 5 trees, position 10 is the most parsimonious and doesn't have any mutations but i don't know if I did this wrong...

Here is a second Q:

I am given two structures here, I calculated the energy for the structure on the left using the tables provided for example at the top their is a 6 base hairpin so table shows that as 4.3 then we have UG to UA and that is -0.5 then their is a 6 base internal loop and that has 2.5 energy. Anyways I did this for the rest of structure 1 and added up all the numbers and got -2.3 so I'm pretty sure its correct.

But I am not sure how to do structure 2... Starting at the top its a 6 base hairpin no problems, then we have UG to UA and that's no problem, but then the internal loop is that a 3 base loop or a 4 base loop? Cos the C is under A I'm not sure if its included in the loop.

That's it from me guys, thanks!

AllisonSharp 11-20-2020 03:18 AM

Hello. I am very familiar with the bioinformatics course. When I was doing my internship at Massachusetts College, we had a course related to an industry perspective. Also, a long time ago I wrote a scientific paper using the service, so I have good knowledge. I can help you out by structuring these questions. Is it still relevant?

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