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-   -   overdispersion and biological replicates (http://seqanswers.com/forums/showthread.php?t=13707)

shilez 08-25-2011 07:10 PM

overdispersion and biological replicates
 
Hi there,

I really appreciate the work of DESeq and EdgeR for taking the overdispersion into account for biological replicates. However assuming when analyzing tumor samples in a few cancer subgroups, do samples in the same subgroup count as "biological replicates" too? Particularly does the overdispersion model in DESeq statistically sound for a potential more variable samples within a subgroup?


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