SEQanswers

SEQanswers (http://seqanswers.com/forums/index.php)
-   Bioinformatics (http://seqanswers.com/forums/forumdisplay.php?f=18)
-   -   Trying to Identifying protein impact by SV amino acid change (http://seqanswers.com/forums/showthread.php?t=87477)

ira.umabharat 02-01-2019 05:44 AM

Trying to Identifying protein impact by SV amino acid change
 
This is a two part question;

(a) To identifying protein change by SV identifiers for genes

I have some structural variants identifiers for some genes, gathered from literature. I was wondering if there is anyway I could identify the protein change in this region. My current theory is to do a blastp to get the protein sequence. From here locate the SV by numbered change. Example of the sv identifiers are like so "ATR A1091V". I found some functional information from HGVS but many from internal data is unknown. Any help to resolve it in a simpler way would be helpful as I have a huge list.

(b) What does SV nomenclature mean ?

Example: "ATR A1091V" Also, I would like to understand what does the nomenclature actually mean. The change to A to V amino acid had in position 1091 ? Is that a copy number with 1 variant ? And if any of them are marked with ' * '; then its numbering to indicating termination ?

Thanks for any help.


All times are GMT -8. The time now is 01:02 PM.

Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2020, vBulletin Solutions, Inc.