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  • norafar
    Junior Member
    • May 2013
    • 5

    #1

    TopHat "configure: No such file or directory"

    Hello All,

    I am a newbie and trying to install TopHat, but am receiving configuration error. I looked through the site and there are several similar errors but the solutions seem to be not applicable in my case.

    Here is what I have done (OSX 10.8.3)

    1) I have downloaded boost (with default prefix of /usr/local)
    2) I had previously downloaded samtool; so:
    3) copied libbam.a to the /usr/local/lib/
    4) copied the headers (*.h) to /usr/local/include/bam/
    5) export PATH=/PATH-to-samtools-0.1.19/:$PATH

    6) tar xvfz tophat-2.0.9.OSX_x86_64.tar
    7) cd tophat-2.0.9.OSX_x86_64
    8) export PATH=$PATH:$PWD

    But when I try ./configure --prefix=/usr/local
    I receive the error that:
    -bash: ./configure: No such file or directory

    When I look in the tophat directory, this error makes sense as there is no ./configure there! Here is what I see there:
    $ ls -1 tophat-2.0.9.OSX_x86_64
    AUTHORS
    COPYING
    README
    bam2fastx
    bam_merge
    bed_to_juncs
    chr25.tophat
    contig_to_chr_coords
    fix_map_ordering
    gtf_juncs
    gtf_to_fasta
    juncs_db
    long_spanning_reads
    map2gtf
    prep_reads
    sam_juncs
    segment_juncs
    sra_to_solid
    tophat
    tophat-fusion-post
    tophat2
    tophat_reports

    I greatly appreciate if you could help me with this problem!

    Thanks!
  • kmcarr
    Senior Member
    • May 2008
    • 1181

    #2
    You have downloaded the precompiled, binary distribution of tophat for OSX. There is no need to run configure and make here, the software is already built and ready to run.

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