View Single Post
Old 07-09-2013, 08:29 AM   #4
Senior Member
Location: Boston,MA

Join Date: Nov 2008
Posts: 121

The most obvious difference is the ability to walk away. A Covaris-you put the tube in-hit start and walk away. For a sonication of 30 minutes-that alone is huge.

In addition, any time you introduce humans into the equation, the results will be less reproducible. A hand held sonicator is going to be different in every persons hands-literally and figuratively.

We have customers that used to use a probe sonicator and is completely switched over to Covaris after seeing the results.

As for the comment about reproducability, you should look at the Covaris website. We just hosted a seminar detailing this exact topic. The outcome is that the same cell line cultured differently will shear differently, so once you determine the best conditions (usually a time course) you can stay with those as long as you don't change the growth conditions.

Last edited by kwaraska; 07-09-2013 at 08:30 AM. Reason: text error
kwaraska is offline   Reply With Quote