An interesting paper integrating Nanopores with optical detection rather than current sensing.
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Well, even ONT took almost 10 years to go from a research paper to a beta device, I think it is too premature to say whether this new tech will amount to anything interesting for now. -
The fine prints of this paper mentioned that this tech is already licensed to ONT. So this is not going to be a competitor of ONT.
If the current minion can be scaled to output 40Gb per box in the near future as ONT claimed, I don't see any big need for even higher throughput in the near future for this tech (or perhaps this tech is the secret behind the 40Gb output?). It is more important to improve the read accuracy to be on par with PacBio IMHO.Comment
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It may not affect ONT, but people (specially graduate students) who put their resources developing software for current ONT platform will be disappointed once they switch to optical detection.Comment
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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