Unconfigured Ad

Collapse
X
 
  • Time
  • Show
Clear All
new posts
  • New2Bioinfo
    Junior Member
    • Dec 2016
    • 4

    #1

    Chipseq - Watson and Crick strand

    Hi,

    I am reading about CHIPseq from this paper and I encountered the following paragraph
    We can take advantage of classical methods and measuring standards
    in the signal-over-noise problem. At the global scale, we use the
    background rate to estimate the ratio of the ChIP signal intensity to the
    landscape intensity; in each called peak region, we take the fold change of
    the ChIP signal intensity to the control signal intensity as the local estimate
    of the signal-to-noise ratio.
    Can anybody please explain how background rate is used to estimate the said ratio. And what exactly is landscape intensity?

    Regards
    Last edited by New2Bioinfo; 12-08-2016, 05:54 AM. Reason: Earlier doubt resolved but new doubt in same topic.
    ----

Latest Articles

Collapse

  • SEQadmin2
    16S/ITS Profiling vs. Shotgun Metagenomics: What Changes in Your Workflow?
    by SEQadmin2




    NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...
    10-30-2026, 06:46 AM
  • SEQadmin2
    Multiomic Liquid Biopsy: What DNA/RNA Panels Reveal That DNA Alone Can’t
    by SEQadmin2



    Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?

    Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating
    ...
    10-14-2026, 09:55 AM

ad_right_rmr

Collapse

News

Collapse

Topics Statistics Last Post
Started by SEQadmin2, 10-28-2026, 09:57 AM
0 responses
32 views
0 reactions
Last Post SEQadmin2  
Started by SEQadmin2, 10-28-2026, 09:51 AM
0 responses
21 views
0 reactions
Last Post SEQadmin2  
Started by SEQadmin2, 10-22-2026, 11:13 AM
0 responses
71 views
0 reactions
Last Post SEQadmin2  
Started by SEQadmin2, 10-22-2026, 10:48 AM
0 responses
48 views
0 reactions
Last Post SEQadmin2  
Working...