Using scRNA-seq to help with snRNA-seq clustering

[Matt.Kanke]

Hi,

I am working with a single nucleotide RNA-seq (snRNAseq) dataset. These are often hard to cluster compared to single cell RNA-seq (scRNAseq). I was wondering if you could combine a snRNAseq and scRNAseq using Seurat's integration method, and after assigning clusters, filter out the scRNAseq cells leaving you with (hopefully) better clustered snRNAseq data to continue the analyses.

Thanks,
Matt