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There's a company in San Diego called Azco Biotech acting as sales representative for Dover. I've read that the Broad has one, although they say that it's not in use for production sequencing. Is this well-intended system still commercially viable? Does anyone want one? It would seem that technology has moved on (e.g., Ion Torrent).
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Rubenken: Thanks for posting. The Polonator is still commercially available, but despite its low upfront and recurring cost, its throughput has lagged behind that of the two major players. That said, we have not been idle, but have had our heads down working to substantially increase its performance. We will shortly be providing an update on our progress, but I expect that we will do that via Julia Karow of In Sequence. Stay tuned.
Kevin
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Genomics studies in neuroscience face a special challenge due to the brain’s complexity and scarcity of samples. Mapping changes in cell type and state using conventional next-generation sequencing methods remains challenging. Advances in technologies like single-cell sequencing, spatial transcriptomics, and long-read sequencing have opened the door to deeper studies of the brain and diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and schizophrenia.
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Cancer survival rates have significantly increased in the last few decades in the United States, reaching a combined 70% 5-year survival rate by 2021. Behind this number, there are years of research to find new therapies, drug targets, and early detection methods. But there is one core challenge that keeps slowing down these advances, and it’s about drug resistance.
There is no single reason why many patients don’t respond to treatment as expected. Cancer is...07-08-2026, 05:17 AM -
Love this - good data definitely starts from good input, and poor input can only give relatively poor data. I particularly like the mention of Nanodrop/absorbance based methods for quantification. It's such a toss up if you'll get an accurate reading or what amounts to a randomly generated number, and a lot of library/sequencing related issues can be traced back to poor quant.07-01-2026, 11:43 AM
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