what is the difference between exome and transcriptome ? how does their assembly differ ?
-
-
is it transcriptome is always time specific whereas exome is whole rna count irrespective of the time? -
The transcriptome consists of all that is transcribed, ie all RNA species including mRNA, miRNA, tRNA, lncRNA, etc. It is usually studied through samples of RNA. You can get the basic idea by reading this: http://en.wikipedia.org/wiki/Transcriptome
The exome refers to the protein coding portion of the genome. It is usually studied through samples of DNA. I'd recommend reading this article for an example of exome sequencing and its applications: http://www.ncbi.nlm.nih.gov/pmc/arti...1/?tool=pubmedComment
-
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...
Comment