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Interesting interview with their CEO here.
Sounds very, very, very much like ONT. Beta's out at the end of the year, commerical in 2013.
Now, one of the most interesting things is that he's quoting price ranges. Sub-$100 disposable chips and sub-$1k chip readers (about 9:30 in the vid and again at 14:30).
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I can't comment on the IP issues (there seems to be so much nanopore IP out there, I don't know how they all keep it straight), but what Genia claims to have over other nanopore companies is their expertise in using analog-to-digital sensors directly on integrated circuits. They say it gives them control over the creation of lipid bilayers, the addition of the protein nanopore, and precise control over the movement of the DNA molecules (back and forth through the pore for multiple reads). They also claim to be able to ramp up to 1M sensors (each with an individual pore) on a 1cm X 1cm chip.
I love what ONT is demonstrating with how their instruments can operate in tandem, but it isn't clear how many independent sensors/pores they'll have per well. Does anyone know?
I've placed what I know about Genia and ONT on BlueSEQ's knowledgebank (along with a dozen other emerging NGS technologies): http://blueseq.com/knowledgebank/emerging-technologies/
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They are presenting tomorrow/today I think, we shall see. My prediction is "not very many". Hope I am wrong.Originally posted by scbaker View PostI love what ONT is demonstrating with how their instruments can operate in tandem, but it isn't clear how many independent sensors/pores they'll have per well. Does anyone know?
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No QuantuMDx in your BlueSEQ's knowledgebank?Originally posted by scbaker View PostI can't comment on the IP issues (there seems to be so much nanopore IP out there, I don't know how they all keep it straight), but what Genia claims to have over other nanopore companies is their expertise in using analog-to-digital sensors directly on integrated circuits. They say it gives them control over the creation of lipid bilayers, the addition of the protein nanopore, and precise control over the movement of the DNA molecules (back and forth through the pore for multiple reads). They also claim to be able to ramp up to 1M sensors (each with an individual pore) on a 1cm X 1cm chip.
I love what ONT is demonstrating with how their instruments can operate in tandem, but it isn't clear how many independent sensors/pores they'll have per well. Does anyone know?
I've placed what I know about Genia and ONT on BlueSEQ's knowledgebank (along with a dozen other emerging NGS technologies): http://blueseq.com/knowledgebank/emerging-technologies/
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Roche gets back in the NGS game with purchase of Genia
After effectively exiting the NGS market in 2013, Roche is making moves to get back into it with their acquisition of Genia for up to $350M ($125 up front and $225 in potential future payments). Read more on our blog.Originally posted by BBoy View Posthttp://www.genomeweb.com/sequencing/...-platform-diff
There are not very many details on Genia's website, but what little is there reads like a carbon copy of Oxford's stuff.
So how does this not infringe on everything Oxford is doing?
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Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.
The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
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With the launch of new single-cell sequencing platforms in 2026, the field stands at an exciting inflection point. This article surveys the most impactful advances in the field and discusses how they’re reshaping research in cancer, immunology, and beyond.
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