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Related Articles TileQC: a system for tile-based quality control of Solexa data.
BMC Bioinformatics. 2008 May 28;9(1):250
Authors: Dolan PC, Denver DR
ABSTRACT: BACKGROUND: Next-generation DNA sequencing technologies such as Illumina's Solexa platform and Roche's 454 approach provide new avenues for investigating genome-scale questions. However, they also present novel analytical challenges that must be met for their effective application to biological questions. RESULTS: Here we report the availability of tileQC, a tile-based quality control system for Solexa data written in the R language. TileQC provides a means of recognizing bias and error in Solexa output by graphically representing data generated by flow cell tiles. The data represented in the images is then made available in the R environment for further analysis and automation of error detection. CONCLUSIONS: TileQC offers a highly adaptable and powerful tool for the quality control of Solexa-based DNA sequence data.
PMID: 18507856 [PubMed - as supplied by publisher]
More...
Related Articles TileQC: a system for tile-based quality control of Solexa data.
BMC Bioinformatics. 2008 May 28;9(1):250
Authors: Dolan PC, Denver DR
ABSTRACT: BACKGROUND: Next-generation DNA sequencing technologies such as Illumina's Solexa platform and Roche's 454 approach provide new avenues for investigating genome-scale questions. However, they also present novel analytical challenges that must be met for their effective application to biological questions. RESULTS: Here we report the availability of tileQC, a tile-based quality control system for Solexa data written in the R language. TileQC provides a means of recognizing bias and error in Solexa output by graphically representing data generated by flow cell tiles. The data represented in the images is then made available in the R environment for further analysis and automation of error detection. CONCLUSIONS: TileQC offers a highly adaptable and powerful tool for the quality control of Solexa-based DNA sequence data.
PMID: 18507856 [PubMed - as supplied by publisher]
More...