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Old 01-18-2010, 11:53 AM   #1
julien
Junior Member
 
Location: Raleigh NC

Join Date: Nov 2009
Posts: 3
Default how critical is the filtering of potential PCR duplicates?

Hello,

I don't really have a good appreciation for how critical it is to remove potential PCR duplicates from the alignments (either via samtools rmdup or picard). It would appear (based on posts in this forum and pipelines that I have found online) that many ??? do not worry about this issue, am I wrong ? It did not seem to affect my data very much but I would like to know how important an issue this is.

Thank you !!!!
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