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Old 02-02-2015, 07:06 AM   #5
westerman
Rick Westerman
 
Location: Purdue University, Indiana, USA

Join Date: Jun 2008
Posts: 1,104
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While Diamond is much faster than BlastX the results are different in that correspondence between the top hit from each program is likely to not be the same. I *think* that this is due to differences in determining the evalues. Digging deeper and taking, say, the top 10 hits will start showing similarities between the programs. This is not to say that Diamond's results are biologically incorrect but you do have to be aware that the programs are not drop-in replacements for each other.
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