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Old 09-04-2014, 12:42 PM   #3
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Location: UK

Join Date: Jan 2010
Posts: 390

We've used SureSelect capture on FFPE samples regularly. Works just fine, but basically there is a trade off, if the DNA is highly fragmented you will run into trouble. You can somewhat ameliorate this by throwing more DNA into the hyb, but the bigger the fragments in your sample, the better it will perform.

We've done exome sequencing on 25 year old FFPE samples. I won't say the data was great, but it worked.
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