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Old 08-27-2015, 11:54 AM   #3
simon_seq
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Location: Cambridge, UK

Join Date: Aug 2012
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Thanks a lot for your quick answer!

May I ask, what are the formal constraints when changing normalization methods, such that the basic concept of DESeq(2) still works? Ie. assumption of a negative binomial distribution, Fisher's exact testing? As long as I transform the data linearly and get count values out, I'm fine to transform the data?
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