View Single Post
Old 01-09-2012, 11:03 AM   #1
Location: California

Join Date: Feb 2011
Posts: 32
Default who coined RNAseq? RNAseq as an alignment first approach only

I have some questions regarding semantics surrounding the term RNAseq:

1. Who coined RNAseq? I was under the impression it was:

Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. (2008). "Mapping and quantifying mammalian transcriptomes by RNA-seq". Nature Methods 5 (7): 621–628. doi:10.1038/nmeth.1226. PMID 18516045.

Is this correct?

2. If Mortazavi et al (2008) coined the term then RNAseq refers to a reference genome based approach and not a de novo assembly approach since the technique described in Mortazavi et al purely reference based.

For clarity I think the term RNAseq should be reserved for an alignment based approach. Any thoughts on this?

Last edited by brachysclereid; 01-09-2012 at 11:05 AM.
brachysclereid is offline   Reply With Quote