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Old 12-14-2012, 12:25 AM   #9
Senior Member
Location: Heidelberg

Join Date: Aug 2010
Posts: 165

Hey zimmernv,

Is there any obvious change that you would expect any differential exon usage regulation between the transgenics and the controls? (e.g. the inserted gene being somehow related to the splicing machinery?)

I guess the exon bining is an attempt to test for all possible exon usage regulation according by testing all unique non-overlapping exonic parts from any transcript, but at the end its an optional step. You could input in DEXSeq with "real" exons. My guess is that it won't make a huge difference, but let me know if I am wrong!

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