Thread: 16S vs shotgun
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Old 04-08-2016, 11:23 AM   #1
fanli
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Location: California

Join Date: Jul 2014
Posts: 198
Default 16S vs shotgun

Have people done detailed comparisons of bacterial communities profiled using amplicon (e.g. 16S) versus shotgun sequencing? I know HMP has done this for certain samples, but I can't seem to find any papers describing their results.

Specifically, I'm looking to see what sort of M^2 values people have seen in Procrustes analysis. For example, Figure 4 of this paper doesn't report M2 values, only p-values which are known to be highly inflated and unreliable...
http://microbiomejournal.biomedcentr...168-015-0110-9
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