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Old 04-30-2020, 05:54 AM   #4
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Location: East Coast USA

Join Date: Feb 2008
Posts: 7,077

Perhaps I am missing a subtle point but since you can control mutation type/rates with would it not be better to go with just that data (#2 in list above)? If you mix reads from mutated and un-mutated reference you can't be sure that you will maintain the fraction of mutations at the same level in new pool?
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