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Old 06-10-2011, 08:51 AM   #2
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Location: Western Australia

Join Date: Feb 2010
Posts: 308

This is a wild guess but I would bet it has to be one of two things: 1) biases generated during PCR amplification of your library. Perhaps the GC content is different near the ends of the chromosomes. Or 2) The ends of the chromosomes fragment more efficiently.
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