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Old 04-20-2017, 06:02 AM   #2
pmiguel
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Location: Purdue University, West Lafayette, Indiana

Join Date: Aug 2008
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And your evidence is? Would be helpful if you gave a review of the evidence of the six papers you reference rather than just stating conclusions.

Some DNA damage/modifications could impact the replication of segments of DNA, of course. But it seems like coming up with a way to assay this would be tricky if you want to use sequencing as the assay. For instance, I presume there is some ligation-site bias in library construction that has nothing to do with the fragmentation method per se.

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Phillip
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