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Old 11-17-2011, 01:05 PM   #10
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Location: Bethesda MD

Join Date: Oct 2009
Posts: 505

If, as you say, you can tolerate discarding 90-95% of the reads, then spiking in a gDNA library at that level will definitely solve your problem. After all, adapter dimers are often present at 5-10% in many libraries (the same % as your desired samples), and sequencing them is not a problem!
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