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Old 07-03-2015, 07:03 PM   #2
Brian Bushnell
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Location: Walnut Creek, CA

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I suppose that summing would give greater statistical power. If you have 10 replicates, each with 1 read mapped to some gene, then the sum would be 10 and the average 1. 1 event is a lot more likely to be noise than 10 events.

Aside from that, averaging and rounding would lose precision for no gain.
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