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Old 10-07-2011, 02:21 AM   #3
henry.wood
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Location: Leeds, UK

Join Date: Apr 2010
Posts: 63
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It may be too late for you to make this choice, but the 454 isn't really the best platform to be doing CNV work. Its strength is the length of the read, but to detect CNVs using read depth, the number of reads is the most important. As long as you have enough bases to align the read to the genome then that is enough.
If you have already got data, then yes, it is possible. There are loads of tools on the wiki that can do the job. Some of them might sulk at the low number of reads you get from 454 data.
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