View Single Post
Old 02-18-2012, 08:04 PM   #17
Senior Member
Location: St. Louis

Join Date: Dec 2010
Posts: 534

Originally Posted by gringer View Post
The bias would increase the chance of two strands having an error at the same location, which would probably mean there'll be some tricky regions that still can't be sequenced accurately, regardless of how many times it is done in parallel.
You sure about this? With the complement strand the sequencer would see not only a completely different series of bases, but bases from the "other" direction, I think. if anything I think the error profile would be remarkably different for complementary strands.
Heisman is offline   Reply With Quote