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Old 03-14-2012, 05:07 AM   #1
pbrand
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Location: Bochum, Germany

Join Date: Feb 2012
Posts: 13
Default help: adjusted p-values in edgeR

Hi everybody,

I am relatively new to RNA-Seq and DE statistics. We have chosen to use edgeR for DE analysis and I understood most functions so far or I could answer them via searching the literature. But now I have a problem in understanding the adjustment for multiple testing.

My questions:
1. Do I have to adjust? Are the not-adjusted p-values useless (In case I have some significant differences in DE when not-adjusted but none after adjustment)?

2. Which adjustment method is the best and why?

Thanks in advance,
philipp
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