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Old 08-09-2017, 10:55 AM   #2
Brian Bushnell
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Location: Walnut Creek, CA

Join Date: Jan 2014
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I think it would be easy to find exonic SNPs that are shared by all or most of the individuals and in expressed genes. It would be difficult to say much about them - for example, even if 100% of reads indicate a SNP that does not mean it's in 100% of the individuals, and if 0% of reads indicate a SNP, that does not mean it's absent in the population. But in general, you should be able to discover approximately which SNPs are present in the population and to what extent. Using simulated data may help determine how accurate this is.
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