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Old 05-19-2019, 11:57 AM   #2
Wolfgang Huber
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Location: Heidelberg, Germany

Join Date: Aug 2009
Posts: 109
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Hi Nicolas

Assertions 2-4 seem OK, but 1 is not correct. The best I could come up with to explain this is in the recent book: https://www.huber.embl.de/msmb/Chap-...ec:multifactor

In particular, note that model formulae are not detecting any genes. They are a concise way of specifying a model with multiple parameters ("betas"), and the next step is saying which particular one of these parameters, or linear combination of them ("contrasts") you care about, and *then* you look for genes with a large value of this (univariate) parameter.

Sorry, I didn't understand the "Question".

Hope this helps (a little) -
Wolfgang
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Wolfgang Huber
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Last edited by Wolfgang Huber; 05-19-2019 at 12:12 PM.
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