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Old 09-04-2012, 02:51 AM   #1
Location: Chandigarh, India

Join Date: Apr 2012
Posts: 15
Default How to differentiate driver mutations from common/random mutations and SNPs in cancer

Hi all,

I am working on RNA-seq data ( our own experimental data) for some cancer types of human. I want to know whether the genes found/mapped in the raw data have mutations significantly different from the normal mutations found in the cells. (i.e. distinguish somatic mutations from germline mutations). Also I want to negate significant driver mutations from the SNPs. So what packages are available for this task (what is the protocol exactly) ?. Also, which databases I have to compare my data with to exclude the obvious mutations/variations in my patient samples?

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