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  • Convert chromosomal position to gene sequence position

    I have a list of mutations with their chromosomal locations like
    chr1:6266188-6266188
    chr22:5443534-5443534 .....

    I know how to fetch a list of genes with ucsc browser and/or galaxy that intersects with my mutations. and their accompanying DNA sequence

    But in order to know wich nucleotide in the gene sequence is mutated I have to know the position in the gene.
    Is there a way to convert the chromosomal position to nucleotide position in a gene. so that I can easy invistigate what kind of mutation it is.
    dream result would be:
    gene1 blabla lenght: 1...789 your mutation is in place 88
    or actaXacta
    or actaNacta

  • #2
    If you fetch gene region from annotation database such as UCSC knowngene.txt, you can easily do it.
    Originally posted by Stephanbio View Post
    I have a list of mutations with their chromosomal locations like
    chr1:6266188-6266188
    chr22:5443534-5443534 .....

    I know how to fetch a list of genes with ucsc browser and/or galaxy that intersects with my mutations. and their accompanying DNA sequence

    But in order to know wich nucleotide in the gene sequence is mutated I have to know the position in the gene.
    Is there a way to convert the chromosomal position to nucleotide position in a gene. so that I can easy invistigate what kind of mutation it is.
    dream result would be:
    gene1 blabla lenght: 1...789 your mutation is in place 88
    or actaXacta
    or actaNacta

    Comment


    • #3
      Now that's exactly my question! If it's so easy, can you explain further
      Last edited by Stephanbio; 12-21-2010, 01:05 AM.

      Comment


      • #4


        is what your are looking for.

        Comment


        • #5
          more open research

          I suggest ANNOVAR for publication in the new journal Open Research Computation--recently introduced elsewhere on this site.

          Comment


          • #6
            Thanx , I think ANNOVAR is exactly what i need
            I'm playing with it right now.

            Comment

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