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  • Scientist III, BioInformatics - Thermo Fisher Scientific

    Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Our four premier brands - Life Technologies, Thermo Scientific, Fisher Scientific and Unity Lab Services - offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

    THE POSITION:

    We are seeking an experienced and motivated bioinformatics scientist for developing cutting-edge applications based on Ion Torrent high-throughput sequencing technologies. The position offers an exciting opportunity to join a dedicated team at Carlsbad, CA, translating state-of-the-art sequencing data to research and clinical applications. Under supervision of a senior manager, the candidate is expected to focus on specific goals of real world impact. Strong communication skills, especially for presenting scientific results, keeping records and working collaboratively in a team are necessary.

    The candidate will divide efforts between improving the core technology of AmpliSeqTM and providing customized data analysis to support bench scientists. Key AmpliSeqTM responsibilities are supporting new product development and monitoring performance of existing panels. The bioinformatics scientist will apply sequence and structural methods to mitigate potential mechanisms for systematic sequencing bias. He/she will translate new product requirements into software prototypes and test in a fast-paced environment. Other data analysis tasks include tracking of sequencing quality metrics, variant calling diagnostics and genome annotations.


    REQUIREMENTS / EDUCATION:
    • Solid knowledge of next-generation sequencing analysis under the Linux environment, with good understanding of software engineering and data analysis principles.
    • Proficiencies in a scripting language (PERL or Python) and a statistical package (R or Matlab) are required, and C/C++/Java skills are big pluses.
    • Experience with PCR primer design, sequence and motif analysis is particularly welcome.
    • PhD graduates in relevant fields or industry veterans with equivalent experience are encouraged to apply.

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    Despite advancements in sequencing platforms and related sample preparation technologies, certain sample types continue to present significant challenges that can compromise sequencing results. Pedro Echave, Senior Manager of the Global Business Segment at Revvity, explained that the success of a sequencing experiment ultimately depends on the amount and integrity of the nucleic acid template (RNA or DNA) obtained from a sample. “The better the quality of the nucleic acid isolated...
    03-22-2024, 06:39 AM
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    Matthew DeSaix, a recent doctoral graduate from Kristen Ruegg’s lab at The University of Colorado, shared that most of his research...
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