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Old 05-24-2019, 09:57 AM   #107
GenoMax
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Location: East Coast USA

Join Date: Feb 2008
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Illumina's software pre-processing takes care of clusters that may be showing mixed signals etc so they may never pass that step. Spantiles=t is mainly for nextSeq, where the clusters are hugh (relatively) and as a result there is a chance they will cross tiles. I believe this was done based on empirical observation Brian had done when he was developing clumpify.
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