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Old 04-20-2017, 02:23 AM   #1
2nelly
Junior Member
 
Location: switzerland

Join Date: Feb 2016
Posts: 7
Default translocation detection question

Hi all,

I am wondering...

how is it possible for tools like breakdancer and lumpy to detect translocations in a sample without using normal bam comparison? The reads aligned against the reference genome, however before the alignment we don t know the exact genomic position that every read came from. So, even if there is a translocation, the group of reads supporting a translocation will be aligned under the correct reference genome position.

Thank you in advance
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