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Old 07-26-2016, 03:37 AM   #2
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Join Date: Feb 2008
Posts: 7,076

Improvement is going to be in the amount of data you get. Q-scores are not a big issue with good libraries now-a-days.

Consider this important point: your libraries would need to meet more stringent criteria for insert size (350-450 bp) to avoid optical duplicates (due to pad hopping). If you have shorter or longer inserts then you may be better off staying with 2000/2500.
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