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Old 01-07-2016, 08:48 AM   #1
ootunaoo
Junior Member
 
Location: US

Join Date: Jan 2016
Posts: 1
Default Questions regarding how to compare 2 genomes

Hi Seqanswers,

I would like to ask several questions regarding how to compare 2 genomes in order to find differences: Assume I have 2 dataset of sequencing data from 2 plants of a same species (e.g. arabidopsis) - 1 plant has normal phenotype, the other has disease phenotype. Theoretically, the disease phenotype is known to be controlled by a single gene, and these 2 plants should have similar genome accept the region that responsible for the phenotype. I would want to somehow compare the 2 genomes to find out differences between 2 plants (in order to find the disease gene).

I'm a newbie in Bioinformatics (also newbie of Seqanswers), I do not know where to start. Would you mind providing me some guides to help me find an approach for my problem? - Projects or publications that have similar object; Documents, internet or books, that I should read; Maybe a suggested pipeline would be great...

Thank you for reading.

P/S: And I am sorry if my english is horrible.
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