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Old 02-28-2014, 04:20 PM   #11
krobison
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Location: Boston area

Join Date: Nov 2007
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Oxford is probably a poor choice for sequencing targeted regions, given that most targeted sequencing is looking for small variations (such as SNPs) and Oxford looks out-of-the-box to not be well suited for this. Also, all of the existing capture schemes are designed around small fragments suitable for short read sequencers. It would seem that capture sequencing is playing to none of Oxford's strengths and against many of its likely weaknesses.
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