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Old 02-18-2012, 09:04 PM   #17
Heisman
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Location: St. Louis

Join Date: Dec 2010
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Quote:
Originally Posted by gringer View Post
The bias would increase the chance of two strands having an error at the same location, which would probably mean there'll be some tricky regions that still can't be sequenced accurately, regardless of how many times it is done in parallel.
You sure about this? With the complement strand the sequencer would see not only a completely different series of bases, but bases from the "other" direction, I think. if anything I think the error profile would be remarkably different for complementary strands.
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