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Old 10-29-2010, 09:59 AM   #1
Nils Homer
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Location: Boston, MA, USA

Join Date: Nov 2008
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Default Short Read Micro re-Aligner Paper

Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA.


A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genome. A novel short-read micro re-aligner, SRMA, that leverages this correlation to better resolve a consensus of the underlying DNA sequence of the targeted genome is described here.
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