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Old 10-12-2013, 10:13 AM   #2
Junior Member
Location: Chicago

Join Date: Oct 2013
Posts: 8

Hi -

I've got a question regarding using Bioconductor. I've been struggling with Bioconductor for the past week - I was under the impression that Bioconductor could be used for 'high-throughput' analysis on large files (500MB+) without any trouble on my laptop.

Specifically - I am trying to do ChIP-seq analysis on a genome wide scale. Unfortunately, I haven't even been able to get the files to load. R tries to load them in their entirely into RAM - I guess I thought it would work with the files without necessarily loading them into memory.

What strategies do people use to work with large files in Bioconductor? Is there some major thing I am missing here?

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