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Old 05-20-2014, 04:18 AM   #4
Devon Ryan
Location: Freiburg, Germany

Join Date: Jul 2011
Posts: 3,480

No, more replicates will still give you a better idea of actual correlation, since you'll be more accurately assessing expression level (and how much histone modification or whatever is actually present). My guess (since you really don't provide enough information for people to know what you're actually attempting) is that you just want to use something like GSEA and look at gene-sets comprised of those genes whose promoters/bodies/whatever show enrichment for your histone modification(s) of interest across groups.
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