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Old 09-13-2010, 04:45 AM   #2
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Location: Boston area

Join Date: Nov 2007
Posts: 747

From the specs I've seen, PacBio will not initially be cost-effective vs. HiSeq in those domains.

Strengths for PacBio are very rapid turnaround, relatively simple sample prep, low cost per run (really "shot") and very long read lengths. In my mind, whole genome sequencing doesn't leverage any of those & quick back-of-envelope calculations put a PacBio human genome at many times an Illumina or SOLiD one.
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