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Old 07-04-2017, 03:51 PM   #4
Location: Honolulu, HI

Join Date: Jul 2015
Posts: 40

Originally Posted by ATϟGC View Post
I have always thought of the NaCl (or another source of Na+ like Sodium acetate) as a co-factor required for an ethanol, isopropanol or PEG-base nucleic acid precipitation. NaCl might precipitate nucleic acids to a degree but I do not think that it is nearly as efficient as alcohols of PEG.
I think that the sodium ions, in this case, may be somehow facilitating the binding of DNA to the carboxylated surface of the beads rather than playing a large role in the actual precipitation.
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