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Old 05-07-2015, 08:39 AM   #6
mbblack
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Location: Research Triangle Park, NC

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Quote:
Originally Posted by stormin View Post
Actually I mean if there are any prior research in what types of protein/genes are typically low expressing. For example, we know housekeeping genes are typically always on and expressed in cell at fairly high levels. What about the lower end?
Well, there are no such things as truly universal housekeeping genes. For any gene that one person has found useful as a housekeeping gene, you can almost certianly find an example where it is differentially expressed or not expressed. Housekeeping genes are context dependent.

Any list of "low expressors" is pointless without identifying species, tissue, life stage and environmental condition at the time of sampling. All you have to do is look at what is known about tissue specific expression profiles to realize there is no inherently universal such gene or genes.
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