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Old 05-08-2015, 05:01 AM   #10
mbblack
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Location: Research Triangle Park, NC

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Perhaps average absolute expression levels for a given wild type tissue may behave that way. But you would not be able to address that question by sequencing whole cell mRNA.

Honestly, I'd be more inclined to think that perhaps mean constituent cellular protein concentrations may behave that way for a given protein in a given tissue or cell type, but not necessarily expression of the genes for that protein. To my thinking, if a relatively invariant constituent protein level is necessary for some functional or regulatory aspect, then expression may likely have to be very labile for that protein in order to maintain relatively constant cellular protein levels over time.

P.S. this paper may appear a bit dated, but its message is still highly relevant to this sort of discussion - it is for yeast: http://citeseerx.ist.psu.edu/viewdoc...=rep1&type=pdf
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Last edited by mbblack; 05-08-2015 at 05:22 AM.
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