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Old 01-02-2012, 02:13 PM   #1
angerusso
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Location: US

Join Date: Oct 2011
Posts: 47
Question Lengths of all genes

Hey,

Hopefully this question is appropriate for this thread (Edited)

1) I need to compute amino acid substitution mutation frequency in a gene and I want to normalize these frequencies across all genes by dividing these frequencies with the respective lengths of the genes.
E.g. (A1T frequency in TP53 frequency) = (# of samples)/1254
My question is where do I find the size of all genes?

2) If I need to compute frequencies of gene mutations in general (containing not just non-synonymous but also insertions and deletion). How would I then normalize the mutation frequency for each gene based on the size? What size would I consider (gene chr position end - gene chr position start?)

Thanks.

Last edited by angerusso; 01-02-2012 at 05:20 PM.
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