Yet another SV detection program. Of course, this one claims to be the best.
I think this may be best utilized in conjunction with algorithms that utilize discordant paired reads like my own BreakWay or Breakdancer or other algorithms like BreakSeq. Also, with Pindel. They do seem to make a case that the best results are obtained by looking for events that are identified by multiple methods.
I do want to point out also that some breakpoints have been identified to the nucleotide level in next gen data in the past. I think the statement about it in the paper is a bit misleading, actually, but perhaps that's true for the couple of examples they put. Still, it's not the first time it's been done nor the only program capable of it (though CREST may be the best at it, and they make a strong case for that).
Regardless, an interesting paper and yet another tool to implement in the murky world of SV detection!
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